Helen E. Collins Laboratory

Investigating Mechanisms Underlying Female Cardiovascular Resilience and Health

O-GlcNAcylation and cardiovascular disease.


Journal article


J. N. Wright, Helen E Collins, A. Wende, J. Chatham
Biochemical Society transactions, 2017

Semantic Scholar DOI PubMed
Cite

Cite

APA   Click to copy
Wright, J. N., Collins, H. E., Wende, A., & Chatham, J. (2017). O-GlcNAcylation and cardiovascular disease. Biochemical Society Transactions.


Chicago/Turabian   Click to copy
Wright, J. N., Helen E Collins, A. Wende, and J. Chatham. “O-GlcNAcylation and Cardiovascular Disease.” Biochemical Society transactions (2017).


MLA   Click to copy
Wright, J. N., et al. “O-GlcNAcylation and Cardiovascular Disease.” Biochemical Society Transactions, 2017.


BibTeX   Click to copy

@article{j2017a,
  title = {O-GlcNAcylation and cardiovascular disease.},
  year = {2017},
  journal = {Biochemical Society transactions},
  author = {Wright, J. N. and Collins, Helen E and Wende, A. and Chatham, J.}
}

Abstract

The post-translational modification of serine and threonine residues of proteins found in numerous subcellular locations by O-linked N-acetylglucosamine (O-GlcNAc) is emerging as a key mediator of many cardiovascular pathophysiological processes. Early studies implicated increased protein O-GlcNAcylation as contributing to the cardiovascular complications associated with diabetes, whereas subsequent studies demonstrated that acute increases in O-GlcNAc levels were protective against ischemia/reperfusion injury. There is now a growing understanding that O-GlcNAc modification of proteins influences numerous cellular functions, including transcription, protein turnover, calcium handling, and bioenergetics. As a result, a more nuanced view of the role of protein O-GlcNAcylation in the cardiovascular system is emerging along with the recognition that it is required for normal cellular function and homeostasis. Consequently, the impact of changes in O-GlcNAc cycling due to stress or disease on the heart is complex and highly dependent on the specific context of these events. The goal of this review is to provide an overview of some of the more recent advances in our understanding of the role O-GlcNAcylation plays in mediating cardiovascular function and disease.


Share


Follow this website


You need to create an Owlstown account to follow this website.


Sign up

Already an Owlstown member?

Log in