The Collins lab is located at the University of Louisville in the Center for Cardiometabolic Science (Formerly known as the Diabetes and Obesity Center). The Centers webpage is located at www.CenterforCardiometabolicScience.org
Historically, females have been understudied in the context of preclinical and clinical trials contributing to an overall reduced knowledge of basic female cardiovascular biology and also how the female heart responds to physiological and pathological stress. Therefore, the overall mission of the Collins lab is to understand the mechanisms contributing to female cardiovascular health and resilience.
Under this larger thematic focus, the Collins lab has several areas of active investigation, they include:
Historically, females have been understudied in the context of preclinical and clinical trials contributing to an overall reduced knowledge of basic female cardiovascular biology and also how the female heart responds to physiological and pathological stress. Therefore, the overall mission of the Collins lab is to understand the mechanisms contributing to female cardiovascular health and resilience.
Under this larger thematic focus, the Collins lab has several areas of active investigation, they include:
Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.
Pathophysiological and etiological mechanisms of peripartum cardiomyopathy and other pregnancy-associated cardiovascular complications.
The response of the female heart to pathological stressors and mechanisms underlying sex-dependent changes in post-infarction remodeling
Pathophysiological and etiological mechanisms of peripartum cardiomyopathy and other pregnancy-associated cardiovascular complications.
The response of the female heart to pathological stressors and mechanisms underlying sex-dependent changes in post-infarction remodeling
Publications
Maternal Cardiovascular Research and Education Should be Prioritized in the US.
Helen E. Collins
Am J Physiol Heart Circ Physiol, 2025
Female Cardioprotection in Ischemia/Reperfusion: Isn't a SUR thing anymore?
Annalara G. Fischer, Helen E. Collins
Journal of Molecular and Cellular Cardiology Plus, 2024
Exercise-induced changes in myocardial glucose utilization during periods of active cardiac growth.
Fulghum KL, Collins HE, Lorkiewicz PK, Cassel TA, Fan TWM, Hill BG
J Mol Cell Cardiol, vol. 191, 2024, pp. 50-62
Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum
Helen E Collins, Barbara T Alexander, Alison S Care, Margie H Davenport, Sandra T Davidge, Mansoureh Eghbali, Dino A Giussani, Martijn F Hoes, Colleen G Julian, Holly A LaVoie, I Mark Olfert, Susan E Ozanne, Egle Bytautiene Prewit, Junie P Warrington, Lubo Zhang, Styliani Goulopoulou
Am J Physiol Heart Circ Physiol , vol. 327(1), 2024, pp. H191-H220.
Guidelines for in vivo models of developmental programming of cardiovascular disease risk
Junie P Warrington, Helen E Collins, Sandra T Davidge, Jussara M do Carmo, Styliani Goulopoulou, Suttira Intapad, Analia S Loria, Jenny L Sones, Loren E Wold, Erin K Zinkhan, Barbara T Alexander
Am J Physiol Heart Circ Physiol , vol. 327(1), 2024, pp. H221-H241.
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Projects
Contact
Helen E Collins, PhD, FAHA
Assistant Professor of Medicine
[email protected]; [email protected]
502-852-9157
Division of Environmental Medicine; Center for Cardiometabolic Science
Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY