Introduction to the Collins Laboratory

Dr. Collins’s research has thus far focused on the study of calcium regulation at the level of the cardiomyocyte and the impact of cardiovascular disease, such as hypertrophy and ischemia/reperfusion injury, and altered circadian rhythms, on store-dependent and store-independent calcium regulation.

The Collins lab is focused on understanding the underlying mechanisms that contribute to sex differences in cardiovascular physiology and the increased risk of adverse cardiovascular events in vulnerable female populations.

Current interests include:

Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy.

Sex-dependent regulation of cardiac metabolism and its impact on post-infarction remodeling.

Publications

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

Helen E Collins, Dingguo Zhang, J. Chatham

Frontiers in Aging, 2022

Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart

Helen E Collins, Joshua C. Anderson, A. Wende, J. Chatham

Physiological reports, 2022

Influence of biological sex and exercise on murine cardiac metabolism

K. Fulghum, Helen E Collins, S. P. Jones, B. Hill

Journal of sport and health science, 2022

Metabolic Signatures of Pregnancy-Induced Cardiac Growth.

K. Fulghum, Juliette B Smith, Julia L Chariker, Lauren F. Garrett, K. Brittian, P. Lorkiewicz, Lindsey McNally, Shizuka Uchida, S. P. Jones, B. Hill, Helen E Collins

American journal of physiology. Heart and circulatory physiology, 2022

Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy

Helen E Collins, M. Kane, S. Litovsky, V. Darley-Usmar, M. Young, J. Chatham, Jianhua Zhang

Frontiers in Aging, 2021

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Projects

Understanding the Mechanisms Contributing to Pregnancy-Induced Cardiac Growth and its Reversal

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy.

Sex-dependent regulation of cardiac metabolism and its impact on post-infarction remodeling.

Contact

Helen E Collins, PhD

Assistant Professor of Medicine

[email protected]

502-852-9157

Division of Environmental Medicine; Diabetes and Obesity Center

University of Louisville

Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY