Investigating Mechanisms Underlying Female Cardiovascular Resilience and Health

Introduction to the Collins Laboratory


Dr. Collins’s research has thus far focused on the study of calcium regulation at the level of the cardiomyocyte and the impact of cardiovascular disease, such as hypertrophy and ischemia/reperfusion injury, and altered circadian rhythms, on store-dependent and store-independent calcium regulation.

The Collins lab is focused on understanding the underlying mechanisms that contribute to sex differences in cardiovascular physiology and the increased risk of adverse cardiovascular events in vulnerable female populations. 

Current interests include:

Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy.

Sex-dependent regulation of cardiac metabolism and its impact on post-infarction remodeling.

Publications


STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases


Helen E Collins, Dingguo Zhang, J. Chatham


Frontiers in Aging, 2022


Influence of biological sex and exercise on murine cardiac metabolism


K. Fulghum, Helen E Collins, S. P. Jones, B. Hill


Journal of sport and health science, 2022


Metabolic Signatures of Pregnancy-Induced Cardiac Growth.


K. Fulghum, Juliette B Smith, Julia L Chariker, Lauren F. Garrett, K. Brittian, P. Lorkiewicz, Lindsey McNally, Shizuka Uchida, S. P. Jones, B. Hill, Helen E Collins


American journal of physiology. Heart and circulatory physiology, 2022


Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy


Helen E Collins, M. Kane, S. Litovsky, V. Darley-Usmar, M. Young, J. Chatham, Jianhua Zhang


Frontiers in Aging, 2021


View all

Contact


Helen E Collins, PhD


Assistant Professor of Medicine


[email protected]


502-852-9157


Division of Environmental Medicine; Diabetes and Obesity Center


University of Louisville


Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY


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