Investigating Mechanisms Underlying Female Cardiovascular Resilience and Health

Introduction to the Collins Laboratory

Dr. Collins’s research has thus far focused on the study of calcium regulation at the level of the cardiomyocyte and the impact of cardiovascular disease, such as hypertrophy and ischemia/reperfusion injury, and altered circadian rhythms, on store-dependent and store-independent calcium regulation.

The Collins lab is focused on understanding the underlying mechanisms that contribute to sex differences in cardiovascular physiology and the increased risk of adverse cardiovascular events in vulnerable female populations. 

Current interests include:

Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy.

Sex-dependent regulation of cardiac metabolism and its impact on post-infarction remodeling.


STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

Helen E Collins, Dingguo Zhang, J. Chatham

Frontiers in Aging, 2022

Influence of biological sex and exercise on murine cardiac metabolism

K. Fulghum, Helen E Collins, S. P. Jones, B. Hill

Journal of sport and health science, 2022

Metabolic Signatures of Pregnancy-Induced Cardiac Growth.

K. Fulghum, Juliette B Smith, Julia L Chariker, Lauren F. Garrett, K. Brittian, P. Lorkiewicz, Lindsey McNally, Shizuka Uchida, S. P. Jones, B. Hill, Helen E Collins

American journal of physiology. Heart and circulatory physiology, 2022

Mitochondrial Morphology and Mitophagy in Heart Diseases: Qualitative and Quantitative Analyses Using Transmission Electron Microscopy

Helen E Collins, M. Kane, S. Litovsky, V. Darley-Usmar, M. Young, J. Chatham, Jianhua Zhang

Frontiers in Aging, 2021

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Helen E Collins, PhD

Assistant Professor of Medicine

[email protected]


Division of Environmental Medicine; Center for Cardiometabolic Science

University of Louisville

Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY