Introduction to the Collins Laboratory

The Collins lab is located at the University of Louisville in the Center for Cardiometabolic Science (Formerly known as the Diabetes and Obesity Center). The Centers webpage is located at www.CenterforCardiometabolicScience.org

Historically, females have been understudied in the context of preclinical and clinical trials contributing to an overall reduced knowledge of basic female cardiovascular biology and also how the female heart responds to physiological and pathological stress. Therefore, the overall mission of the Collins lab is to understand the mechanisms contributing to female cardiovascular health and resilience.

Under this larger thematic focus, the Collins lab has several areas of active investigation, they include:

Understanding the mechanisms that contribute to pregnancy-induced cardiac growth and its reversal.

Pathophysiological and etiological mechanisms of peripartum cardiomyopathy and other pregnancy-associated cardiovascular complications.

The response of the female heart to pathological stressors and mechanisms underlying sex-dependent changes in post-infarction remodeling.

Publications

Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise

Emily B Schulman-Geltzer, Helen E Collins, Bradford G Hill, Kyle L Fulghum

Curr Heart Fail Rep., 2023

Female Cardiovascular Biology and Resilience in the Setting of Physiological and Pathological Stress

Helen E. Collins

Redox Biology, 2023

Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.

Xiaosen Ouyang, Sayan Bakshi, Gloria A. Benavides, Zhihuan Sun, Gerardo Hernandez-Moreno, Helen E. Collins, Mariame S. Kane, Silvio Litovsky, Martin E. Young, John C. Chatham, Victor Darley-Usmar, Adam R. Wende, Jianhua Zhang.

Physiological Reports, vol. 11(9), 2023, pp. e15686

STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases

Helen E. Collins, Dingguo Zhang, John C. Chatham

Frontiers in Aging, 2022

Cardiomyocyte stromal interaction molecule 1 is a key regulator of Ca2+‐dependent kinase and phosphatase activity in the mouse heart

Helen E Collins, Joshua C. Anderson, Adam R. Wende, John C. Chatham

Physiological reports, 2022

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