Introduction to the Collins Laboratory
Historically, females have been understudied in the context of preclinical and clinical trials contributing to an overall reduced knowledge of basic female cardiovascular biology and also how the female heart responds to physiological and pathological stress. Therefore, the overall mission of the Collins lab is to understand the mechanisms contributing to female cardiovascular health and resilience.
Under this larger thematic focus, the Collins lab has several areas of active investigation, they include:
Pathophysiological and etiological mechanisms of peripartum cardiomyopathy and other pregnancy-associated cardiovascular complications.
The response of the female heart to pathological stressors and mechanisms underlying sex-dependent changes in post-infarction remodeling.
Publications
Coordinated Metabolic Responses Facilitate Cardiac Growth in Pregnancy and Exercise
Emily B Schulman-Geltzer, Helen E Collins, Bradford G Hill, Kyle L Fulghum
Curr Heart Fail Rep., 2023
Female Cardiovascular Biology and Resilience in the Setting of Physiological and Pathological Stress
Helen E. Collins
Redox Biology, 2023
Cardiomyocyte ZKSCAN3 regulates remodeling following pressure-overload.
Xiaosen Ouyang, Sayan Bakshi, Gloria A. Benavides, Zhihuan Sun, Gerardo Hernandez-Moreno, Helen E. Collins, Mariame S. Kane, Silvio Litovsky, Martin E. Young, John C. Chatham, Victor Darley-Usmar, Adam R. Wende, Jianhua Zhang.
Physiological Reports, vol. 11(9), 2023, pp. e15686
STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases
Helen E. Collins, Dingguo Zhang, John C. Chatham
Frontiers in Aging, 2022
Helen E Collins, Joshua C. Anderson, Adam R. Wende, John C. Chatham
Physiological reports, 2022
View all
Projects
Contact
Helen E Collins, PhD, FAHA
Assistant Professor of Medicine
[email protected]; [email protected]
502-852-9157
Division of Environmental Medicine; Center for Cardiometabolic Science
Delia Baxter Building, Room 321C, University of Louisville, 580 South Preston Street, Louisville, KY