Investigating Mechanisms Underlying Female Cardiovascular Resilience and Health

Protein O-GlcNAcylation and Cardiovascular (Patho)physiology*


Journal article


S. A. Marsh, Helen E Collins, J. Chatham
The Journal of Biological Chemistry, 2014

Semantic Scholar DOI PubMed
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APA
Marsh, S. A., Collins, H. E., & Chatham, J. (2014). Protein O-GlcNAcylation and Cardiovascular (Patho)physiology*. The Journal of Biological Chemistry.

Chicago/Turabian
Marsh, S. A., Helen E Collins, and J. Chatham. “Protein O-GlcNAcylation and Cardiovascular (Patho)Physiology*.” The Journal of Biological Chemistry (2014).

MLA
Marsh, S. A., et al. “Protein O-GlcNAcylation and Cardiovascular (Patho)Physiology*.” The Journal of Biological Chemistry, 2014.


Abstract

Our understanding of the role of protein O-GlcNAcylation in the regulation of the cardiovascular system has increased rapidly in recent years. Studies have linked increased O-GlcNAc levels to glucose toxicity and diabetic complications; conversely, acute activation of O-GlcNAcylation has been shown to be cardioprotective. However, it is also increasingly evident that O-GlcNAc turnover plays a central role in the delicate regulation of the cardiovascular system. Therefore, the goals of this minireview are to summarize our current understanding of how changes in O-GlcNAcylation influence cardiovascular pathophysiology and to highlight the evidence that O-GlcNAc cycling is critical for normal function of the cardiovascular system.


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